William A. Zeiger

Jul 1, 2023 | eneuro.org | Brenda Gail Vasquez |Ashley Cao |William A. Zeiger

DiscussionHere we describe a set of simple adaptations that can be applied to an existing upright microscope to allow high-sensitivity IOSI. These adaptations make use of readily available commercial parts, can be implemented in an afternoon (or less), require no custom machining, and do not require any specialized skills in optics, electronics, circuit design, or programming.

Jun 12, 2023 | jamanetwork.com | Jeff Bronstein |William A. Zeiger |Chao Peng |Alberto J Espay

Abandoning the Proteinopathy Paradigm in Parkinson Disease—Not So Fast To the Editor Espay and Okun1 recently proposed abandoning the proteinopathy paradigm in Parkinson disease (PD) in favor of a “proteinopenia” hypothesis. Loss of function as a possible mechanism for PD and other neurodegenerative diseases is not a new idea, and we agree that multiple potential mechanisms underlying neurodegeneration should be investigated.