Jelle J Goeman

Nov 12, 2024 | biorxiv.org | Marije Henrieke Sluiskes |Hein Putter |Marian Beekman |Jelle J Goeman

AbstractThe increasing availability of multi-outcome data in health research presents new opportunities for understanding complex health processes, such as ageing. Ageing is a multifaceted process, encompassing both lifespan and healthspan, as well as the onset of age-related diseases. To model this complexity, we propose the penalized reduced rank regression model for multi-outcome survival data (penalized survRRR), which identifies shared latent factors driving multiple outcomes.

Nov 13, 2023 | biorxiv.org | Jelle J Goeman |Marian Beekman |Hein Putter |Marije Henrieke Sluiskes

AbstractAging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of individuals, suggesting that biological age may provide a more nuanced understanding of the aging process.