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Nov 12, 2024 | 
biorxiv.org | Marije Henrieke Sluiskes |Hein Putter |Marian Beekman |Jelle J Goeman
AbstractThe increasing availability of multi-outcome data in health research presents new opportunities for understanding complex health processes, such as ageing. Ageing is a multifaceted process, encompassing both lifespan and healthspan, as well as the onset of age-related diseases. To model this complexity, we propose the penalized reduced rank regression model for multi-outcome survival data (penalized survRRR), which identifies shared latent factors driving multiple outcomes.
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Nov 11, 2024 | 
analyticalsciencejournals.onlinelibrary.wiley.com | Bingshu He |Rawi Ramautar |Marian Beekman |P. Eline Slagboom
AA arachidonic acid BHT butylated hydroxytoluene BuOH 1-butanol EMA European Medicines Agency EPA eicosapentaenoic acid ISTD internal standard LLE liquid–liquid extraction MeOH methanol MTBE methyl tert-butyl ether PGs prostaglandins PUFAs polyunsaturated fatty acids QC quality control SRM selected reaction monitoring 1 Introduction Oxylipins are a group of signaling lipids derived from polyunsaturated fatty acids (PUFAs) through enzymatic or non-enzymatic oxidation processes. Non-esterified...
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Oct 30, 2024 | 
nature.com | Bette Loef |Marian Beekman |Dorret I. Boomsma |M. Arfan Ikram |Annemarie Koster |Frits R Rosendaal
AbstractObesity may affect an individual’s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
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Jul 24, 2024 | 
medrxiv.org | Mar Rodriguez-Girondo |P. Eline Slagboom |Marian Beekman |Kerstin Alexandra Schorr
The authors have declared no competing interest. P.E. Slagboom, M. Beekman, and L.C.P.G.M de Groot have received funding from the Vitality Oriented Innovations for the Lifecourse of the Ageing Society (VOILA) Consortium [ZonMw 457001001]. All authors declare no conflict of interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Jul 5, 2024 | 00262-1/fulltext?rss=yes&sz=64)
rbmojournal.com | P. Eline Slagboom |Marian Beekman |Femke Roelofs |Frank J.M. Broekmans
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Apr 19, 2024 | 00262-1/abstract&sz=64)
rbmojournal.com | Frank JM Broekmans |Marian Beekman
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Mar 6, 2024 | 
nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more
AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
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Nov 30, 2023 | 
mdpi.com | Daniele Bizzarri |Marian Beekman |P. Eline Slagboom |Marcel J. T
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Nov 13, 2023 | 
biorxiv.org | Jelle J Goeman |Marian Beekman |Hein Putter |Marije Henrieke Sluiskes
AbstractAging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of individuals, suggesting that biological age may provide a more nuanced understanding of the aging process.
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Sep 28, 2023 | 
nature.com | Maryam Kavousi |Haojie Lu |Chani J. Hodonsky |Joris Deelen |Xiuqing Guo |Leo-Pekka Lyytikäinen | +31 more
AbstractCoronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population.
