Hein Putter

Nov 12, 2024 | biorxiv.org | Marije Henrieke Sluiskes |Hein Putter |Marian Beekman |Jelle J Goeman

AbstractThe increasing availability of multi-outcome data in health research presents new opportunities for understanding complex health processes, such as ageing. Ageing is a multifaceted process, encompassing both lifespan and healthspan, as well as the onset of age-related diseases. To model this complexity, we propose the penalized reduced rank regression model for multi-outcome survival data (penalized survRRR), which identifies shared latent factors driving multiple outcomes.

Nov 13, 2023 | biorxiv.org | Jelle J Goeman |Marian Beekman |Hein Putter |Marije Henrieke Sluiskes

AbstractAging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of individuals, suggesting that biological age may provide a more nuanced understanding of the aging process.

Jun 23, 2023 | journals.plos.org | Oxford Hospitals Trust |John Mulvey |Hein Putter |Sadr Shaheed

Loading metrics Open Access Peer-reviewedResearch Article AbstractHypothermic machine perfusion (HMP) provides preservation superior to cold storage and may allow for organ assessment prior to transplantation. Since flavin mononucleotide (FMN) in perfusate has been proposed as a biomarker of organ quality during HMP of donor livers, the aim of this study was to validate FMN as a biomarker for organ quality in the context of HMP preserved kidneys.