Jennifer L. Rowsey

May 16, 2024 | jci.org | Dominik Saul |Madison L. Doolittle |Jennifer L. Rowsey |Mitchell N. Froemming

ResearchAgingBone biologyOpen Access | 10.1172/JCI179834 J Clin Invest. https://doi.org/10.1172/JCI179834. Copyright © 2024, Saul et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Feb 7, 2024 | biorxiv.org | Dominik Saul |Madison L. Doolittle |Jennifer L. Rowsey |Mitchell N. Froemming

AbstractCells expressing features of senescence, including upregulation of p21 and p16, appear transiently following tissue injury, yet the properties of these cells or how they contrast with age-induced senescent cells remains unclear. Here, we used skeletal injury as a model and identified the rapid appearance following fracture of p21+ cells expressing senescence markers, mainly as osteochondroprogenitors (OCHs) and neutrophils.