Jennifer Wilson

2 months ago | biorxiv.org | Emily R Bozich |Xiaolu Guo |Jennifer Wilson |Alexander Hoffmann

AbstractSingle-cell studies of signal transduction have revealed complex temporal dynamics that determine downstream biological function. For example, the stimulus-specific dynamics of the transcription factor NFκB specify stimulus-specific gene expression programs, and loss of specificity leads to disease. Thus, it is intriguing to consider drugs that may restore signaling specificity in disease contexts, or reduce activity but maintain signaling specificity to avoid unwanted side effects.