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2 months ago | 
biorxiv.org | Emily R Bozich |Xiaolu Guo |Jennifer Wilson |Alexander Hoffmann
AbstractSingle-cell studies of signal transduction have revealed complex temporal dynamics that determine downstream biological function. For example, the stimulus-specific dynamics of the transcription factor NFκB specify stimulus-specific gene expression programs, and loss of specificity leads to disease. Thus, it is intriguing to consider drugs that may restore signaling specificity in disease contexts, or reduce activity but maintain signaling specificity to avoid unwanted side effects.
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Mar 8, 2025 | 
medium.com | Alexander Hoffmann
Alexander Hoffmann·Follow6 min read·--Losing access to a Yahoo account can be a frustrating and stressful experience, especially if it contains important emails, contacts, or sensitive information. While hacking and unauthorized access to accounts are illegal and unethical, there is a legitimate and ethical way to recover a compromised Yahoo account: by hiring a certified hacker.
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Feb 11, 2025 | 
biorxiv.org | Eiji Nakamura |Franco Blanchini |Giulia Giordano |Alexander Hoffmann
AbstractCells have the capacity to encode and decode information in the temporal features of molecular signals. Many pathways, for example, generate either sustained or pulsatile responses depending on the context, and such diverse temporal behaviors have a profound impact on cell fate. Here we focus on how molec- ular pathways can convert the temporal features of dynamic signals, in particular how they can convert transient signals into persistent downstream events and vice versa.
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Jan 13, 2025 | 
pubs.rsc.org | Sonja Herres-Pawlis |Tobias Seitz |RWTH Aachen |Marcel Walbeck |Alexander Hoffmann
Electron transfer kinetics of a series of copper complexes with tripodal tetradentate guanidine quinolinyl ligands†
Copper complexes of tripodal ligands have been used as model systems for electron transfer proteins for decades, displaying a broad range of electron self-exchange rates. We herein report a group of six tripodal tetradentate triarylamine ligands which display a varying number of guanidine and 2-methylquinolinyl moieties.
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Jan 8, 2025 | 
thelancet.com | Alexander Hoffmann |Gilbert S. Omenn |Diego R. Mazzotti
ArticlesVolume 7, Issue 1e35-e43Open access aDepartment of Biomedical Informatics, Medical School, Harvard University, Boston, MA, USA bDepartment of Internal Medicine, University of Texas at Southwestern, Dallas, TX, USA cOffice of Informatics and Information Technology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA dComputational Medicine and Bioinformatics, Internal Medicine, Human Genetics, Environmental Health, University of Michigan, Ann Arbor,...
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Jan 7, 2025 | 
science.org | Dana M. Cairns |Carolina Chávez |Kelly Lin |Alexis Malveaux |Quen Cheng |Alexander Hoffmann | +2 more
Research ArticleINNATE IMMUNITY Access the full articleView all access options to continue reading this article. Supplementary MaterialsMDAR Reproducibility ChecklistREFERENCES AND NOTES1K. M. Sheu, A. Hoffmann, Functional hallmarks of healthy macrophage responses: Their regulatory basis and disease relevance. Annu. Rev. Immunol. 40, 295–321 (2022). 2M. G. Netea, J. Domínguez-Andrés, L. B. Barreiro, T. Chavakis, M. Divangahi, E. Fuchs, L. A. B. Joosten, J. W. M. van der Meer, M. M. Mhlanga, W. J. M. Mulder, N. P. Riksen, A.
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Nov 15, 2024 | 
pubs.rsc.org | Tobias Seitz |Alexander Hoffmann |Sonja Herres-Pawlis |Marcel Walbeck
Electron Transfer Kinetics of a Series of Copper Complexes with Tripodal Tetradentate Guanidine Quinolinyl Ligands
Copper complexes of tripodal ligands have been used as model systems for electron transfer proteins for decades, displaying a broad range of electron self-exchage rates. We herein report a group of six tripodal tetradentate triarylamine ligands which display a varying number of guaninidine and 2-methylquinolinyl moierties.
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Nov 13, 2024 | 
rheinpfalz.de | Alexander Hoffmann
Vor 160 Jahren wird in London die erste Gaslicht-Ampel installiert und schnell wieder demontiert. Zum Durchbruch verhelfen dem Lichtsignal erst zwei Tüftler aus den USA. Gegen 1870 ist London mit seinen fast vier Millionen Einwohnern die größte Stadt der Welt, es ist die Hauptstadt des Empire, der Weltmacht Großbritannien. Auf seinen Straßen jedoch herrscht wachsendes Verkehrschaos wie in einem riesigen Dorf, verursacht durch unzählige Pferdefuhrwerke, Pferdeomnibusse und eine Flut von Fußgängern.
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Nov 6, 2024 | 
rheinpfalz.de | Alexander Hoffmann
Anfangs wollte es niemand kaufen. Der Durchbruch mit der fiesen Rauskegelei gelang Erfinder Josef Friedrich Schmidt ausgerechnet im Ersten Weltkrieg. Er versucht alles, um wirtschaftlichen Erfolg zu haben – doch die zündende Idee lässt lange Jahre auf sich warten. Josef Friedrich Schmidt kommt 1871 im oberpfälzischen Bitte loggen Sie sich ein um den Artikel im Klartext zu sehen.
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Oct 15, 2024 | 00779-2&sz=64)
cell.com | Katherine M. Sheu |Computational Biosciences |Alexander Hoffmann
Keywords inducible gene expression dynamics single cell trajectory ensembles information theory machine learning macrophage context dependence stimulus-response specificity gene expression trajectories Introduction Macrophages are immune sentinel cells that deploy their diverse functions in response to exposure to pathogens or activating stimuli.1,2 Immune response genes not only differ in the magnitudes of induction but also show distinctive temporal dynamics evident in the gene expression...
