Ya Cui

Apr 5, 2024 | cell.com | Byrska-Bishop M |Ya Cui |Wenbin Ye |Jingyi Li

Highlights • A biobank-scale reference of 0.86 million TRs derived from 338,963 humans • A TR reference map for diverse ancestries, including 39.5% non-European samples • Critical insights into the prevalence of ancestry-specific TR disorders • An invaluable resource for interpreting TR expansions in diseases Summary The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions,...

Mar 18, 2024 | nature.com | Ya Cui |Wei Li |Jeremy Rich

AbstractGlioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance. Pharmacologic modulators of ubiquitin ligases and deubiquitinases are under development for cancer and other diseases.