Ya Cui

1 month ago | medrxiv.org | Stine Jacobsen |Jeppe Dyrberg Andersen |Ya Cui |Wei Li

The authors have declared no competing interest. S.N.N.C was supported by a research grant from the Danish Cardiovascular Academy, which is funded by the Novo Nordisk Foundation, grant number NNF20SA0067242 and the Danish Heart Foundation. M.T.O. and P.J.S. were supported by a Novo Nordisk Foundation Tandem Programme grant (NNF23OC0081817, The Calmodulinopathy Research Program: Unraveling the Mechanistic Link between Calmodulin Mutations and Clinical Phenotypes).

Apr 5, 2024 | cell.com | Byrska-Bishop M |Ya Cui |Wenbin Ye |Jingyi Li

Highlights • A biobank-scale reference of 0.86 million TRs derived from 338,963 humans • A TR reference map for diverse ancestries, including 39.5% non-European samples • Critical insights into the prevalence of ancestry-specific TR disorders • An invaluable resource for interpreting TR expansions in diseases Summary The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions,...

Mar 18, 2024 | nature.com | Ya Cui |Wei Li |Jeremy Rich

AbstractGlioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance. Pharmacologic modulators of ubiquitin ligases and deubiquitinases are under development for cancer and other diseases.