Jhan-Jie Peng

Sep 20, 2023 | nature.com | Noelia Maldonado-Pérez |Alessio Bevilacqua |Jhan-Jie Peng |Anouk Lepez |Kung-Chi Kao |Francisco Martin | +4 more

AbstractProtective immunity against pathogens or cancer is mediated by the activation and clonal expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid proliferation and effector functions, naive T cells switch their quiescent metabolism to an anabolic metabolism through increased levels of aerobic glycolysis, but also through mitochondrial metabolism and oxidative phosphorylation, generating energy and signalling molecules1,2,3.

Apr 14, 2023 | science.org | Paul Bastard |Nora Ruef |Li Ran |Jhan-Jie Peng

ReviewCANCER IMMUNOLOGYJhan-Jie Peng https://orcid.org/0000-0001-8923-9234, Limei Wang, [...] , Zhiyu Li, Cheng-Lung Ku https://orcid.org/0000-0002-0643-2256 [email protected], and Ping-Chih Ho https://orcid.org/0000-0003-3078-3774 [email protected]+2 authors fewerAuthors Info & AffiliationsAbstractChimeric antigen receptor (CAR) T cells have achieved true clinical success in treating hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of cancer therapy.