Jiandong Liu

Jan 13, 2025 | pubs.acs.org | Fang Li |Jiandong Liu |Huaping Wang |Yurong Ren

Oct 17, 2024 | mdpi.com | Jiandong Liu |Jun Du |Fei Wang |De Liu

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Dec 10, 2023 | nature.com | Qiang Zhu |Laura Herring |Jiandong Liu |Michelle Mendiola Pla

AbstractThe serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of dysfunctional mitochondria, and defects in this process contribute to a variety of cardiometabolic and neurological diseases. Although recent evidence indicates that dynamic actin remodeling plays an important role in PINK1/Parkin-mediated mitochondrial autophagy (mitophagy), the underlying signaling mechanisms remain unknown.