Michelle Mendiola Pla

Dec 10, 2023 | nature.com | Qiang Zhu |Laura Herring |Jiandong Liu |Michelle Mendiola Pla

AbstractThe serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of dysfunctional mitochondria, and defects in this process contribute to a variety of cardiometabolic and neurological diseases. Although recent evidence indicates that dynamic actin remodeling plays an important role in PINK1/Parkin-mediated mitochondrial autophagy (mitophagy), the underlying signaling mechanisms remain unknown.

Aug 8, 2023 | frontiersin.org | Rutgers Robert Wood Johnson |Cristiano Amarelli |John Stone |Michelle Mendiola Pla

Introduction The improvement of graft preservation remains a key goal in lung transplantation, with the ultimate objective of increasing the number and quality of transplants. Graft preservation is a key topic given the necessity of maintaining the quality of the harvested organ after it has been removed from the donor and remains in a vulnerable state, subject to ischemic damage.