Jianjun Chen

Apr 20, 2024 | nature.com | Jiamin Guo |Li Du |Rui Su |Zhenhua Chen |Guido Marcucci |Lili Wang | +3 more

AbstractTargeting the metabolic dependencies of acute myeloid leukemia (AML) cells is a promising therapeutical strategy. In particular, the cysteine and methionine metabolism pathway (C/M) is significantly altered in AML cells compared to healthy blood cells. Moreover, methionine has been identified as one of the dominant amino acid dependencies of AML cells.

Jan 20, 2024 | dx.doi.org | Jianjun Chen |Zhiyu Li |Wei Chong Tan |Yu Xie

Jan 8, 2024 | nature.com | Ke Xu |Jianjun Chen

AbstractOur previous work has shown that d-ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations in RIB levels and depression as well as potential RIB participation in depressive disorder is yet unknown. Here, a reanalysis of metabonomics data from depressed patients and depression model rats is performed to clarify whether the increased RIB level is positively correlated with the severity of depression.

Jun 6, 2023 | nature.com | Peng Zheng |Jianjun Chen

AbstractEvidences have shown that both LRFN5 and OLFM4 can regulate neural development and synaptic function. Recent genome-wide association studies on major depressive disorder (MDD) have implicated LRFN5 and OLFM4, but their expressions and roles in MDD are still completely unclear. Here, we examined serum concentrations of LRFN5 and OLFM4 in 99 drug-naive MDD patients, 90 drug-treatment MDD patients, and 81 healthy controls (HCs) using ELISA methods.

Apr 27, 2023 | dx.doi.org | Junwei Zhang |Zhen Sun |Jianjun Chen

A two-dimensional transport dispersive (TD) model, based on the Navier–Stokes equation, describing an energy conservation of fluid motion, and a one-dimensional TD model, were built to describe the diffusions of glycolic acid (GA) and NaCl in the axial and radial directions in a preparative column. The elution and breakthrough curves of GA and NaCl were simulated with the models, and the instantaneous concentrations of GA and NaCl in the column were further studied.