Zhenhua Chen

Jan 16, 2025 | mdpi.com | Zhenhua Chen |Jie Xu |Ronghua Zhang |Yuxuan Wang

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Jul 16, 2024 | cell.com | Meiling Chen |Chao Shen |Yi Chen |Zhenhua Chen

Highlights • Metformin substantially sensitizes FLT3-mutated AML cells to gilteritinib in vitro • Metformin synergizes with gilteritinib in treating FLT3-ITD AML in vivo • Metformin and gilteritinib cooperatively target PLK1/STAT5-ERK-mTOR in FLT3-ITD AML • Metformin plus TKI offers a potent and cost-effective therapy for FLT3-ITD AML Summary Fms-like tyrosine kinase 3 (FLT3) mutations, present in over 30% of acute myeloid leukemia (AML) cases and dominated by FLT3-internal tandem duplication...

Apr 20, 2024 | nature.com | Jiamin Guo |Li Du |Rui Su |Zhenhua Chen |Guido Marcucci |Lili Wang | +3 more

AbstractTargeting the metabolic dependencies of acute myeloid leukemia (AML) cells is a promising therapeutical strategy. In particular, the cysteine and methionine metabolism pathway (C/M) is significantly altered in AML cells compared to healthy blood cells. Moreover, methionine has been identified as one of the dominant amino acid dependencies of AML cells.

Nov 2, 2023 | frontiersin.org | Guangzhou Women |Tomasz Szczepanski |Adolfo Martinez |Zhenhua Chen

IntroductionAcute lymphoblastic leukemia (ALL) is a malignant tumor with the highest morbidity, accounting for approximately 25% of cancer diagnoses in children under the age of 15 years (1). With therapeutics’ development, pediatric ALL’s long-term survival rate has reached more than 90%. However, nearly 10%–20% of ALL children relapse after initial complete remission. The mechanism of relapse susceptibility of pediatric ALL is still undiscovered.

Jul 7, 2023 | frontiersin.org | Zhenhua Chen |Bo Zhang

1 IntroductionCurcumin, an orange-yellow polyphenolic compound originating from TCM, has attracted much attention owing to its anti-inflammatory, anti-bacterial, anti-oxidant, and other biological activities. Many studies have focused on the anti-tumor activity of curcumin.