Jianlong Wang

Dec 30, 2024 | nature.com | Jianlong Wang

AbstractPluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the nucleolus-specific RNA helicase DDX18 is essential for maintaining the pluripotency of human embryonic stem cells.

Oct 20, 2024 | onlinelibrary.wiley.com | Siyang He |Nanosystems Chinese Academy |Zheng Yang |Jianlong Wang

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202415534-sup-0001-SuppMat.docx7.5 MB Supporting Information adfm202415534-sup-0002-MovieS1.mp49.4 MB Supplemental Movie 1 adfm202415534-sup-0003-MovieS2.mp42.9 MB Supplemental Movie 2 adfm202415534-sup-0004-MovieS3.mp410.9 MB Supplemental Movie 3 adfm202415534-sup-0005-MovieS4.mp419.6 MB Supplemental Movie 4 References 1, , , , , Agric.

Sep 23, 2024 | onlinelibrary.wiley.com | Jianlong Wang |Shandong Province |Dong Wang |Yujing Jiang

State Key Laboratory of Mining Disaster Prevention and Control Co–Founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao, China State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Beijing, China Dong Wang, State Key Laboratory of Mining Disaster Prevention and Control Co–Founded by Shandong Province and the Ministry of Science and Technology, Shandong...

Apr 9, 2024 | dx.doi.org | Yuqi Wang |Jianlong Wang |Hengyu Li |Qi Gao

RETURN TO ARTICLES ASAPPREVEnergy, Environmenta...Energy, Environmental, and Catalysis ApplicationsNEXT Yuqi Wang Guangzhou Institute of Blue Energy, Knowledge City, Huangpu District, Guangzhou 510555, China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing 100049, China , Jianlong Wang Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of...

Sep 16, 2023 | nature.com | Marie-Pierre St-Onge |Jianlong Wang |Ying Wei |Sanja Jelic |Memet Emin |Brooke Aggarwal | +6 more

Sleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal evidence that mild, prolonged sleep restriction mimicking “real-life” conditions impairs endothelial function, a key step in the development and progression of cardiovascular disease, in healthy female persons. However, the underlying mechanisms are unclear. In model organisms, sleep restriction increases oxidative stress and upregulates antioxidant response via induction of the antioxidant regulator nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Here, we assessed directly endothelial cell oxidative stress and antioxidant responses in healthy female persons (n = 35) after 6 weeks of mild sleep restriction (1.5 h less than habitual sleep) using randomized crossover design. Sleep restriction markedly increased endothelial oxidative stress without upregulating antioxidant response. Using RNA-seq and a predicted protein–protein interaction database, we identified reduced expression of endothelial Defective in Cullin Neddylation-1 Domain Containing 3 (DCUN1D3), a protein that licenses Nrf2 antioxidant responses, as a mediator of impaired endothelial antioxidant response in sleep restriction. Thus, sleep restriction impairs clearance of endothelial oxidative stress that over time increases cardiovascular risk. Trial Registration: NCT02835261