Marie-Pierre St-Onge

Oct 30, 2024 | sciencedirect.com | J. Bitzer |Megan E. Petrov |Marie-Pierre St-Onge |Mark S. Baron

The separation of sexuality from fertility, which is called contraception, is based on the understanding of human reproductive physiology, which in this context includes the understanding of the processes in the female and male body, and how these processes interact in producing a pregnancy. Based on this knowledge contraceptive methods have been developed, which are different and specific for females and males.

Sep 16, 2023 | nature.com | Marie-Pierre St-Onge |Jianlong Wang |Ying Wei |Sanja Jelic |Memet Emin |Brooke Aggarwal | +6 more

Sleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal evidence that mild, prolonged sleep restriction mimicking “real-life” conditions impairs endothelial function, a key step in the development and progression of cardiovascular disease, in healthy female persons. However, the underlying mechanisms are unclear. In model organisms, sleep restriction increases oxidative stress and upregulates antioxidant response via induction of the antioxidant regulator nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Here, we assessed directly endothelial cell oxidative stress and antioxidant responses in healthy female persons (n = 35) after 6 weeks of mild sleep restriction (1.5 h less than habitual sleep) using randomized crossover design. Sleep restriction markedly increased endothelial oxidative stress without upregulating antioxidant response. Using RNA-seq and a predicted protein–protein interaction database, we identified reduced expression of endothelial Defective in Cullin Neddylation-1 Domain Containing 3 (DCUN1D3), a protein that licenses Nrf2 antioxidant responses, as a mediator of impaired endothelial antioxidant response in sleep restriction. Thus, sleep restriction impairs clearance of endothelial oxidative stress that over time increases cardiovascular risk. Trial Registration: NCT02835261

May 3, 2023 | bigthink.com | Marie-Pierre St-Onge

The future, my mom used to say, belongs to those who wake up early. L’avenir appartient à ceux qui se lèvent tôt. She’d say this as we drove to early ice skating practices on those cold winter mornings growing up in Quebec. As it turns out, science may be proving her right — though perhaps not in exactly the way she thought. I am a researcher who specializes in understanding the links between diet, sleep and health.

May 2, 2023 | freethink.com | Marie-Pierre St-Onge

The future, my mom used to say, belongs to those who wake up early. L’avenir appartient à ceux qui se lèvent tôt. She’d say this as we drove to early ice skating practices on those cold winter mornings growing up in Quebec. As it turns out, science may be proving her right — though perhaps not in exactly the way she thought. I am a researcher who specializes in understanding the links between diet, sleep and health.