Sanja Jelic

1 week ago | health.com | Lindsay Curtis |Sanja Jelic

katleho Seisa / Getty Images Pneumonia occurs when germs like bacteria, viruses, or fungi infect your lungs. Your immune system releases white blood cells to fight the infection, causing inflammation that can lead to symptoms like coughing and trouble breathing. A pneumonia cough is often deep and loud, and it may linger for several weeks after your other symptoms are gone. What Are the Characteristics of a Pneumonia Cough?

2 weeks ago | verywellhealth.com | Patty Weasler |Sanja Jelic

As we sleep, our brain moves through four stages and two phases: non-rapid eye movement (NREM) and rapid eye movement (REM). The brain has four stages within the NREM phase. Each stage and phase of sleep plays an important role in our overall health. Halfpoint Images / Getty Images Stage 1: NREM The first stage of NREM sleep is the transition from wakefulness to sleep. This brief transition typically lasts only a few minutes. During this stage, the heart rate and breathing begin to slow down.

Sep 16, 2023 | nature.com | Marie-Pierre St-Onge |Jianlong Wang |Ying Wei |Sanja Jelic |Memet Emin |Brooke Aggarwal | +6 more

Sleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal evidence that mild, prolonged sleep restriction mimicking “real-life” conditions impairs endothelial function, a key step in the development and progression of cardiovascular disease, in healthy female persons. However, the underlying mechanisms are unclear. In model organisms, sleep restriction increases oxidative stress and upregulates antioxidant response via induction of the antioxidant regulator nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Here, we assessed directly endothelial cell oxidative stress and antioxidant responses in healthy female persons (n = 35) after 6 weeks of mild sleep restriction (1.5 h less than habitual sleep) using randomized crossover design. Sleep restriction markedly increased endothelial oxidative stress without upregulating antioxidant response. Using RNA-seq and a predicted protein–protein interaction database, we identified reduced expression of endothelial Defective in Cullin Neddylation-1 Domain Containing 3 (DCUN1D3), a protein that licenses Nrf2 antioxidant responses, as a mediator of impaired endothelial antioxidant response in sleep restriction. Thus, sleep restriction impairs clearance of endothelial oxidative stress that over time increases cardiovascular risk. Trial Registration: NCT02835261