Jiaqian Luo

Jan 13, 2025 | nature.com | Dan Li |Li Yao |Fengshen Kuo |Jiaqian Luo |Alison Smith |Dong Gao | +7 more

AbstractMembers of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes.