Dong Gao

Jan 13, 2025 | nature.com | Dan Li |Li Yao |Fengshen Kuo |Jiaqian Luo |Alison Smith |Dong Gao | +7 more

AbstractMembers of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes.

Feb 14, 2024 | nature.com | Lei Chen |Chong Zhang |Ruidong Xue |Mo Liu |Yin Wang |Nanhai Jiang | +9 more

AbstractOver half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1,2,3. However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4,5,6,7,8, with current analyses of HCC mainly from non-HBV-enriched populations9,10. Here we initiated the Chinese Liver Cancer Atlas (CLCA) project and performed deep whole-genome sequencing (average depth, 120×) of 494 HCC tumours.