Fengshen Kuo

Jan 13, 2025 | nature.com | Dan Li |Li Yao |Fengshen Kuo |Jiaqian Luo |Alison Smith |Dong Gao | +7 more

AbstractMembers of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes.

Jun 19, 2023 | nature.com | Fengshen Kuo |Mustafa Buyukozkan |Tricia Park |A. Ari Hakimi |Andrew M. Intlekofer |Jan Krumsiek

AbstractTumour metabolism is controlled by coordinated changes in metabolite abundance and gene expression, but simultaneous quantification of metabolites and transcripts in primary tissue is rare. To overcome this limitation and to study gene–metabolite covariation in cancer, we assemble the Cancer Atlas of Metabolic Profiles of metabolomic and transcriptomic data from 988 tumour and control specimens spanning 11 cancer types in published and newly generated datasets.