Jiaqin Li

Jul 1, 2024 | cell.com | Haiyan Zhao |Jiaqin Li |Yufei Xiang |Sohail Malik

Highlights • MED26 and the CDK8 kinase module (CKM) compete for interaction with Mediator (MED) • MED26-MED can bind RNA Pol II whereas CKM-MED, targeted by nuclear receptors (NRs), cannot • NR binding to CKM-MED enables CKM exchange for MED26 and RNA Pol II interaction • Transcription activation by NRs hinges on modulation of RNA Pol II binding to CKM-MED Summary The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all...