Haiyan Zhao

Nov 15, 2024 | biorxiv.org | Bingjie Wang |Haiyan Zhao

AbstractTick-borne encephalitis virus (TBEV) is primarily transmitted to humans through tick bites, leading to symptoms of encephalitis with a fatality rate ranging from 1% to 30%, depending on the virus subtype. Currently, only inactivated virus vaccines are available for human use, though break-through infections can still occur. Therefore, developing new vaccines against TBEV is crucial. In this study, we designed and characterized a novel nanoparticle-based TBEV envelope (E) dimer vaccine.

Jul 1, 2024 | cell.com | Haiyan Zhao |Jiaqin Li |Yufei Xiang |Sohail Malik

Highlights • MED26 and the CDK8 kinase module (CKM) compete for interaction with Mediator (MED) • MED26-MED can bind RNA Pol II whereas CKM-MED, targeted by nuclear receptors (NRs), cannot • NR binding to CKM-MED enables CKM exchange for MED26 and RNA Pol II interaction • Transcription activation by NRs hinges on modulation of RNA Pol II binding to CKM-MED Summary The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all...

Apr 12, 2024 | onlinelibrary.wiley.com | Haiyan Zhao |Dong Li |Yuqi Liu |Tianqi Zhang

Supporting Information Filename Description ppl14287-sup-0001-Appendix_S1.pdfPDF document, 1.1 MB Appendix S1. Supplementary Figures ppl14287-sup-0002-Appendix_S2.xlsExcel spreadsheet, 4.9 MB Appendix S2. Supplementary Tables REFERENCES , , , , , , , and (2006) Integration of plant responses to environmentally activated phytohormonal signals. Science, 311, 91–94. , , and (1999) Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis.