Sohail Malik

Jan 20, 2025 | hitconsultant.net | Sohail Malik

For Medicare Advantage Organizations (MAOs), the summer months have historically been defined by the high stakes, tight turnarounds and document management challenges of the Annual Enrollment Period (AEP).

Jul 1, 2024 | cell.com | Haiyan Zhao |Jiaqin Li |Yufei Xiang |Sohail Malik

Highlights • MED26 and the CDK8 kinase module (CKM) compete for interaction with Mediator (MED) • MED26-MED can bind RNA Pol II whereas CKM-MED, targeted by nuclear receptors (NRs), cannot • NR binding to CKM-MED enables CKM exchange for MED26 and RNA Pol II interaction • Transcription activation by NRs hinges on modulation of RNA Pol II binding to CKM-MED Summary The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all...

Aug 2, 2023 | nature.com | Sohail Malik |Robert G. Roeder

AbstractThe RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in eukaryotic transcription regulation, and its formation is the major rate-limiting step in transcriptional activation. Diverse cellular signals borne by transcriptional activators converge on this large, multiprotein assembly and are transduced via intermediary factors termed coactivators.