Jiaxi Cai

Jul 17, 2024 | nature.com | Qiaozhen Ye |Jiaxi Cai |Huilin Zhou |Aaron T. Whiteley

AbstractUbiquitination pathways have crucial roles in protein homeostasis, signalling and innate immunity1,2,3. In these pathways, an enzymatic cascade of E1, E2 and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) to target-protein lysine residues4.

Nov 20, 2023 | embopress.org | Sunbin Deng |Jiaxi Cai |Stephen Harrison |Huilin Zhou

Introduction Kinetochores assemble at centromeres by interacting with a variant histone H3 known as centromere protein A (CENP-A) in vertebrates and as Cse4 in Saccharomyces cerevisiae and other point-centromere yeast. CENP-A and Cse4 deviate from canonical histone H3 at residues interspersed in the histone core and in the sequence and length of the N-terminal segment (Fig 1A).

Sep 26, 2023 | biorxiv.org | Qiaozhen Ye |Jiaxi Cai |Lydia R Chambers |Minheng Gong

AbstractUbiquitination and related pathways play crucial roles in protein homeostasis, signaling, and innate immunity. In these pathways, an enzymatic cascade of E1, E2, and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) to target-protein lysine residues.

Jun 7, 2023 | biorxiv.org | Sunbin Deng |Jiaxi Cai |Stephen Harrison |Huilin Zhou

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