Qiaozhen Ye

Nov 21, 2024 | biorxiv.org | Minheng Gong |Qiaozhen Ye |Yajie Gu |Lydia R Chambers

AbstractBacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encode predicted E1, E2, E3, deubiquitinase, and ubiquitin-like proteins. Some of these pathways have recently been shown to function in anti-bacteriophage immunity, but the biological functions of others remain unknown.

Jul 17, 2024 | nature.com | Qiaozhen Ye |Jiaxi Cai |Huilin Zhou |Aaron T. Whiteley

AbstractUbiquitination pathways have crucial roles in protein homeostasis, signalling and innate immunity1,2,3. In these pathways, an enzymatic cascade of E1, E2 and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) to target-protein lysine residues4.

Sep 26, 2023 | biorxiv.org | Qiaozhen Ye |Jiaxi Cai |Lydia R Chambers |Minheng Gong

AbstractUbiquitination and related pathways play crucial roles in protein homeostasis, signaling, and innate immunity. In these pathways, an enzymatic cascade of E1, E2, and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) to target-protein lysine residues.