Jiaying Zheng

Oct 22, 2024 | biorxiv.org | Jiaying Zheng |Lingxiao Wang |Shunyi Zhao |Katayoun Ayasoufi

AbstractIn the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword: they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-gated proton channel Hv1, predominantly expressed in myeloid cells, as a crucial regulator of their physiological functions. We discovered a strong correlation between increased Hv1 expression and poor prognosis in glioblastoma patients.

Apr 30, 2024 | virologyj.biomedcentral.com | Wangquan Ji |Yu Chen |Shujie Han |Bowen Dai |Shuang Li |Zijie Li | +8 more

For this retrospective study, we included a total of 96 hospitalized pediatric patients diagnosed with HMPV infection who were admitted to Children’s Hospital Affiliated to Zhengzhou University between 29 April and 5 June 2023 (Fig. 1). Children’s Hospital Affiliated to Zhengzhou University (Henan Children’s Hospital) is the largest tertiary pediatric referral hospital in central China with 2,200 beds, which is located in Zhengzhou of Henan province.

Feb 12, 2024 | biorxiv.org | Shunyi Zhao |Lingxiao Wang |Yue Liang |Jiaying Zheng

AbstractMicroglia actively survey the brain and dynamically interact with neurons to maintain brain homeostasis. Microglial Gi-protein coupled receptors (Gi-GPCRs) play a critical role in microglia-neuron communications. However, the impact of temporally activating microglial Gi signaling on microglial dynamics and neuronal activity in the homeostatic brain remains largely unknown.