Katayoun Ayasoufi

Dec 25, 2024 | cell.com | Jessica Waibl Polania |Alexandra M Hoyt-Miggelbrink |William H. Tomaszewski |Lucas P Wachsmuth |Selena J. Lorrey |Daniel Wilkinson | +5 more

Keywords T cell exhaustion tumor-associated macrophage tumor microenvironment tumor immunology immunotherapy brain tumor brain metastasis glioblastoma Introduction Brain tumors, both primary and metastatic, continue to herald poor survival.1,2 Immunotherapies, such as immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR) T cells, hold promise for improving outcomes but remain only marginally effective within the intracranial confines.3,4 This has been especially true in the...

Oct 22, 2024 | biorxiv.org | Jiaying Zheng |Lingxiao Wang |Shunyi Zhao |Katayoun Ayasoufi

AbstractIn the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword: they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-gated proton channel Hv1, predominantly expressed in myeloid cells, as a crucial regulator of their physiological functions. We discovered a strong correlation between increased Hv1 expression and poor prognosis in glioblastoma patients.

Jun 13, 2023 | biorxiv.org | Anthony D. Umpierre |Bohan Li |Katayoun Ayasoufi |Shunyi Zhao

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.