Shunyi Zhao

Oct 22, 2024 | biorxiv.org | Jiaying Zheng |Lingxiao Wang |Shunyi Zhao |Katayoun Ayasoufi

AbstractIn the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword: they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-gated proton channel Hv1, predominantly expressed in myeloid cells, as a crucial regulator of their physiological functions. We discovered a strong correlation between increased Hv1 expression and poor prognosis in glioblastoma patients.

Feb 12, 2024 | biorxiv.org | Shunyi Zhao |Lingxiao Wang |Yue Liang |Jiaying Zheng

AbstractMicroglia actively survey the brain and dynamically interact with neurons to maintain brain homeostasis. Microglial Gi-protein coupled receptors (Gi-GPCRs) play a critical role in microglia-neuron communications. However, the impact of temporally activating microglial Gi signaling on microglial dynamics and neuronal activity in the homeostatic brain remains largely unknown.

Jan 4, 2024 | nature.com | Koichiro Haruwaka |Yanlu Ying |Anthony D. Umpierre |Min-Hee Yi |Vaclav Kremen |Tao Xie | +3 more

AbstractMicroglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase their dynamic process surveillance and interact more closely with neurons. However, the functional significance of microglial process dynamics and neuronal interaction under anesthesia is largely unknown. Using in vivo two-photon imaging in mice, we show that microglia enhance neuronal activity after the cessation of isoflurane anesthesia.

Jun 13, 2023 | biorxiv.org | Anthony D. Umpierre |Bohan Li |Katayoun Ayasoufi |Shunyi Zhao

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Apr 6, 2023 | biorxiv.org | Lingxiao Wang |Shunyi Zhao |Wenjing Zhang |Jiaying Zheng

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