Jie Xiong

Nov 25, 2024 | nature.com | Jie Xiong

AbstractCryptosporidium parvum is a zoonotic parasite of the intestine and poses a threat to human and animal health. However, it is difficult to obtain a large number of oocysts for genome sequencing using in vitro culture. To address this challenge, we employed the strategy of whole-genome amplification of 10 oocysts followed by long-read sequencing and obtained a high-quality genome assembly of C. parvum IIdA19G1 subtype isolated from a pre-weaning calf with diarrhea.

Nov 11, 2024 | onlinelibrary.wiley.com | Bingchen Guo |Yutong Guo |Jie Xiong |Bo Wang

Introduction Heart failure (HF) is a complex clinical syndrome resulting from cardiac remodelling due to multiple pathophysiological mechanisms. It is the final manifestation of most cardiovascular diseases. Chronic HF tends to be complex and presents as a heterogeneous disease, associated with multiple risk factors, symptoms, and complications, as well as pathophysiological mechanisms that remain poorly understood (Figure 1). Consequently, the clinical management of HF remains challenging.

Mar 27, 2024 | nature.com | Jie Xiong

AbstractBalantidium ctenopharyngodoni is identified as the sole ciliate species that exclusively resides within the hindgut of grass carp with high prevalence and intensity. In this study, the successful cultivation of B. ctenopharyngodoni enabled us to collect enough cells for genome sequencing. Consequently, we acquired a high-quality genome assembly spanning 68.66 Mb, encompassing a total of 22,334 nanochromosomes.

Mar 20, 2024 | nature.com | Bin Cao |Jie Xiong

AbstractAccelerating the discovery of advanced materials is crucial for modern industries, aerospace, biomedicine, and energy. Nevertheless, only a small fraction of materials are currently under experimental investigation within the vast chemical space. Materials scientists are plagued by time-consuming and labor-intensive experiments due to lacking efficient material discovery strategies. Artificial intelligence (AI) has emerged as a promising instrument to bridge this gap.

Feb 12, 2024 | nature.com | Jie Xiong |Wei Zhang

AbstractAggresomes are the product of misfolded protein aggregation, and the presence of aggresomes has been correlated with poor prognosis in cancer patients. However, the exact role of aggresomes in tumorigenesis and cancer progression remains largely unknown. Herein, the multiomics screening reveal that OTUD1 protein plays an important role in retaining ovarian cancer stem cell (OCSC) properties.