Jingdong Cheng

Jan 13, 2025 | nature.com | Pengyu Fan |Aixia Song |Jiwei Chen |Qi Zhang |Jingdong Cheng |Congling Xu | +2 more

AbstractChromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. Pharmacologically targeting these regulators, particularly the transcription-activating BET proteins, has emerged as a promising approach in cancer therapy, yet intrinsic or acquired resistance frequently occurs, with poorly understood mechanisms.

Sep 27, 2024 | nature.com | Jingdong Cheng

AbstractEpigenetic readers frequently affect gene regulation, correlate with disease prognosis, and hold significant potential as therapeutic targets for cancer. Zinc finger MYND-type containing 11 (ZMYND11) is notably recognized for reading the epigenetic marker H3.3K36me3; however, its broader functions and mechanisms of action in cancer remain underexplored.