Jiwei Chen

Jan 13, 2025 | nature.com | Pengyu Fan |Aixia Song |Jiwei Chen |Qi Zhang |Jingdong Cheng |Congling Xu | +2 more

AbstractChromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. Pharmacologically targeting these regulators, particularly the transcription-activating BET proteins, has emerged as a promising approach in cancer therapy, yet intrinsic or acquired resistance frequently occurs, with poorly understood mechanisms.

Jun 14, 2024 | nature.com | Jiwei Chen

AbstractAs the most promising advanced energy storage system, lithium-sulfur batteries (LSBs) are highly favored by the researchers because of their advantages of high energy density (2500 W h kg−1), low cost and non-pollution.

Apr 15, 2024 | jci.org | Ke Li |Wei Liu |Hang Yu |Jiwei Chen

CorrigendumOpen Access | 10.1172/JCI181374 Published inVolume 134, Issue 8onApril 15, 2024J Clin Invest. 2024;134(8):e181374. https://doi.org/10.1172/JCI181374. © 2024 Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Feb 15, 2024 | jci.org | Ke Li |Wei Liu |Hang Yu |Jiwei Chen

AbstractIntroductionColorectal cancer (CRC) is the third most common malignancy, and metastasis is the major cause of mortality (1). Liver or peritoneal metastasis is common among patients with CRC, leading to a poor prognosis and short overall survival (2, 3). Therefore, there is an urgent need to develop effective strategies to improve the prognosis of patients with metastatic CRC. Immune checkpoint blockades (ICBs) bring hope for long-term survival of cancer patients.

Aug 22, 2023 | nature.com | Cheng Zeng |Jiwei Chen |fei chen

AbstractThe major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic. Here, we dissect the role of LSD1 and its demethylase activity in gene regulation and cell fate transition.