Jingyi Zhang

Dec 10, 2024 | mdpi.com | Hongshuang Wei |Kexin Liu |Jingyi Zhang |Kun Guo

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Oct 21, 2024 | nature.com | Jingyi Zhang |Xu Zhao |Ce Feng Liu |Cheng Cai |Jing Tang |Qingfeng Du | +1 more

Diabetic cardiomyopathy (DCM) is a cardiovascular complication of diabetes mellitus with a poor prognosis and is the leading cause of death in diabetic patients. Sleep deficiency is not only recognized as an important risk factor for the development of type 2 DM, but is also associated with increased morbidity and mortality of cardiovascular disease. The underlying role and mechanisms of sleep restriction (SR) in DCM are far from clear. The KK/Upj-Ay mouse model of T2 DM was used as a study subject, and the small animal ultrasound imaging system was used to detect the function of the heart; immunopathological staining was used to clarify the histo-structural pathological alterations of the heart; and TUNEL staining, qPCR, transmission electron microscopy (TEM), and ELISA kits were used to detect apoptosis, oxidative stress, inflammation, and mitochondrial damage, and related molecular alterations. SR led to a significant increase in mortality, cardiac hypertrophy, necrosis, glycogen deposition and fibrosis further deteriorated in DM KK mice. SR increased cardiomyocyte death in KK mice through the Bax/Bcl2 pathway. In addition to this, SR not only exacerbated the inflammatory response, but also aggravated mitochondrial damage and promoted oxidative stress in KK mice through the PRDM16-PGC-1α pathway. Overall, SR exacerbates structural alterations and dysfunction through inflammation, oxidative stress, and apoptosis in DM KK mice, increasing the risk of death. Clinicians and diabetic patients are prompted to pay attention to sleep habits to avoid accelerating the transition of DCM to heart failure and inducing death due to poor sleep habits.

Sep 18, 2024 | mdpi.com | Ling Zhu |Jun Liu |Jingyi Zhang |Shuyuan Jiang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Sep 15, 2024 | routledge.com | Jingyi Zhang

New Dramaturgies of Contemporary Opera is the first and only book that approaches the dramaturgy of contemporary opera from the unique perspectives of living practitioners (composers, librettists, directors, producers, singers, dramaturgs, and administrators) who provide valuable first-hand insight into the coming into being of an opera today.

Sep 1, 2024 | monthlyreview.org | Jingyi Zhang

is a PhD student at the Department of International Development, King’s College London. Smitha Radhakrishnan, Making Women Pay: Microfinance in Urban India (Durham: Duke University Press, 2022), 272 pages, $27.95, paperback. Microfinance has become a salient sector for poverty reduction in the developing world since its inception in the 1980s.