Xu Zhao

Oct 21, 2024 | nature.com | Jingyi Zhang |Xu Zhao |Ce Feng Liu |Cheng Cai |Jing Tang |Qingfeng Du | +1 more

Diabetic cardiomyopathy (DCM) is a cardiovascular complication of diabetes mellitus with a poor prognosis and is the leading cause of death in diabetic patients. Sleep deficiency is not only recognized as an important risk factor for the development of type 2 DM, but is also associated with increased morbidity and mortality of cardiovascular disease. The underlying role and mechanisms of sleep restriction (SR) in DCM are far from clear. The KK/Upj-Ay mouse model of T2 DM was used as a study subject, and the small animal ultrasound imaging system was used to detect the function of the heart; immunopathological staining was used to clarify the histo-structural pathological alterations of the heart; and TUNEL staining, qPCR, transmission electron microscopy (TEM), and ELISA kits were used to detect apoptosis, oxidative stress, inflammation, and mitochondrial damage, and related molecular alterations. SR led to a significant increase in mortality, cardiac hypertrophy, necrosis, glycogen deposition and fibrosis further deteriorated in DM KK mice. SR increased cardiomyocyte death in KK mice through the Bax/Bcl2 pathway. In addition to this, SR not only exacerbated the inflammatory response, but also aggravated mitochondrial damage and promoted oxidative stress in KK mice through the PRDM16-PGC-1α pathway. Overall, SR exacerbates structural alterations and dysfunction through inflammation, oxidative stress, and apoptosis in DM KK mice, increasing the risk of death. Clinicians and diabetic patients are prompted to pay attention to sleep habits to avoid accelerating the transition of DCM to heart failure and inducing death due to poor sleep habits.

Sep 1, 2024 | mdpi.com | Xinchun Zhu |Yang Wu |Xu Zhao |Yunchen Yang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Aug 21, 2024 | mdpi.com | Kai Wang |Xiang Tao |Shouyu Zhang |Xu Zhao

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Aug 15, 2024 | pubs.rsc.org | Hongjing Liu |Xueli Liu |Xu Zhao |Ruochen Xi

Predicting and screening high-performance polyimide membranes using negative correlation based deep ensemble methods† Polyimide polymer membranes have become critical materials in gas separation and storage applications due to their high selectivity and excellent permeability. However, with over 107 known types of polyimides, relying solely on experimental research means potential high-performance candidates are likely to be overlooked.

Feb 19, 2024 | dx.doi.org | Zhong Chen |Xu Zhao |Bo Gao |Liangliang Xu

RETURN TO ARTICLES ASAPPREVApplications of Poly...Applications of Polymer, Composite, and Coating MaterialsNEXTZhong ChenNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, P. R.