Jinjun Wu

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Jinjun Wu

AbstractNuclear speckles are nuclear membraneless organelles in higher eukaryotic cells playing a vital role in gene expression. Using an in situ reverse transcription–based sequencing method, we study nuclear speckle–associated human transcripts. Our data indicate the existence of three gene groups whose transcripts demonstrate different speckle localization properties: stably enriched in nuclear speckles, transiently enriched in speckles at the pre–messenger RNA stage, and not enriched.

Jul 12, 2023 | frontiersin.org | pranav prabhakar |Jinjun Wu |Ali Wahab

1 IntroductionColorectal cancer (CRC) ranks third among the globally most prevalent cancers, in terms of incidence and mortality (Sheng et al., 2020). The morbidity and mortality of CRC are consistently increasing, which poses a serious threat to the general population’s health (Jian et al., 2020).