Jinpeng Sun

May 22, 2024 | nature.com | Lijie Wu |Yuan Pei |Yiran Wu |Jie Cheng |Fan Yang |Jinpeng Sun | +1 more

AbstractBitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is also widely expressed in extra-gustatory tissues, suggesting its additional roles in diverse physiological processes and potential therapeutic applications3.

Oct 27, 2023 | biorxiv.org | Xiao Yu |Jinpeng Sun

AbstractEquilibrioception is essential for the perception and navigation of mammals in the three-dimensional world. The mechanoelectrical transduction (MET) process in vestibular hair cells is believed to play central roles in positional and motional sensation. However, the direct equilibrioception sensor at the molecular level is not clear, and the mechanism underlying the MET process in vestibular hair cells remains elusive.

Oct 27, 2023 | biorxiv.org | Xiao Yu |Jinpeng Sun

AbstractThe maintenance of normal balance sensing is a fundamental prerequisite for virtually every activity of daily life. As one set most important balance information collectors, vestibular hair cells convert mechanical stimuli from head movement into electrical signals through a mechanoelectrical transduction (MET) process. The molecular mechanism underlying equilibrioception and MET in vestibular hair cells is not well understood but is generally believed to be mediated by ion channels.