Yiran Wu

May 22, 2024 | nature.com | Lijie Wu |Yuan Pei |Yiran Wu |Jie Cheng |Fan Yang |Jinpeng Sun | +1 more

AbstractBitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is also widely expressed in extra-gustatory tissues, suggesting its additional roles in diverse physiological processes and potential therapeutic applications3.

Jul 8, 2023 | biorxiv.org | Zhibin Zhang |Xi Lin |Ling Wei |Yiran Wu

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Mar 15, 2023 | pubs.acs.org | Cuixia Li |Yiran Wu |Wenli Wang |Lu Xu

Despite the essential roles of Frizzled receptors (FZDs) in mediating Wnt signaling in embryonic development and tissue homeostasis, ligands targeting FZDs are rare. A few antibodies and peptide modulators have been developed that mainly bind to the family-conserved extracellular cysteine-rich domain of FZDs, while the canonical binding sites in the transmembrane domain (TMD) are far from sufficiently addressed.