Jiyoon Kim

1 week ago | dailymaverick.co.za | Tristen Taylor |Jiyoon Kim |Ingrid Gercama |Nathalie Bertrams

By Tristen Taylor, Jiyoon Kim, Ingrid Gercama and Nathalie Bertrams – 15 April 2025 Don't want to see this?

Jan 6, 2025 | cell.com | Sofia Brito |Jinyoung Kim |Youngdo Jeong |Wooseon Choi |Gang Lee |Kentaro Oh-hashi | +10 more

Nov 21, 2024 | nature.com | Wilson X. Mai |Kai Song |Nicholas Bayley |Jiyoon Kim |Henan Zhu |Pauline Young | +14 more

Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynamics, is an alternative method to anticipate drug responses. It is unclear whether integrating genomic and functional features of solid tumours can provide unique insight into therapeutic vulnerabilities. We perform combined molecular and functional characterization, via BH3 profiling of the intrinsic apoptotic machinery, in glioma patient samples and derivative models. We identify that standard-of-care therapy rapidly rewires apoptotic signaling in a genotype-specific manner, revealing targetable apoptotic vulnerabilities in gliomas containing specific molecular features (e.g., TP53 WT). However, integration of BH3 profiling reveals high mitochondrial priming is also required to induce glioma apoptosis. Accordingly, a machine-learning approach identifies a composite molecular and functional signature that best predicts responses of diverse intracranial glioma models to standard-of-care therapies combined with ABBV-155, a clinical drug targeting intrinsic apoptosis. This work demonstrates how complementary functional and molecular data can robustly predict therapy-induced cell death. Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

Nov 12, 2024 | cell.com | Yiqian Gu |Ann Ly |Sara Rodriguez |Sara Rodríguez |Hanwei Zhang |Jiyoon Kim | +8 more

Keywords small cell cancers small cell bladder cancer neuroendocrine prostate cancer PD-1 blockade immunochemotherapy clinical trial single-cell sequencing T cell receptor sequencing Introduction Small cell carcinomas (SCCs) are aggressive malignancies found in multiple tissue types including the lung, bladder, prostate, ovaries, and breast.1 They share common histologic features such as small, round-to-oval cells with high nuclear-to-cytoplasm ratios, inconspicuous nucleoli, and incomplete...

Feb 29, 2024 | targetednews.com | Jiyoon Kim

Bryn Mawr College: Faculty Publication - Assistant Professor of Economics Jiyoon Kim February 29, 2024BRYN MAWR, Pennsylvania, Feb. 29 (TNSres) -- Bryn Mawr College issued the following news:The Effects of Paid Family Leave--Does it Help Fathers' Health, Too? (https://link.springer.com/article/10.1007/s00148-024-00994-0)Source: J Popul Econ 37, 19 (2024). https://doi.org/10.1007/s00148-024-00994-0Publication Type: Journal ArticleAbstract: I investigate the effects of California's paid famil . . .