Kai Song

Dec 20, 2024 | mdpi.com | Kai Song

1. IntroductionAronia melanocarpa (black chokeberry) is renowned for its rich polyphenol content and potent antioxidant capacity, which have gained it widespread application in the food and health sectors in recent years. Its fruits are abundant in antioxidants such as anthocyanins, proanthocyanidins, and phenolic acids, which effectively neutralize free radicals, thereby helping to prevent various diseases associated with oxidative stress [1,2,3,4].

Dec 9, 2024 | onlinelibrary.wiley.com | Kai Song |Dong Wang |Yaoxing Bian |Runrui Li

Conflict of Interest The authors declare no conflict of interest. References 1, , , Nat. Commun. 2022, 13, 7879. 2, , , Nat. Photonics 2019, 13, 13. 3, , , , Nat. Commun. 2021, 12, 4516. 4, , , , Phys. Rev. A 1995, 52, R3429. 5, Phys. Rev. A 2008, 78, 061802. 6, , , , , , Phys. Rev. Lett. 2005, 94, 183602. 7, , , , , Photonics Res. 2022, 10, 104. 8, , , , , Opt. Express 2023, 31, 13943. 9, , , , , , , , , Appl. Phys. Lett. 2023, 123, 024005. 10, , , , , , , , Photonics Res. 2024, 12, 226.

Nov 21, 2024 | nature.com | Wilson X. Mai |Kai Song |Nicholas Bayley |Jiyoon Kim |Henan Zhu |Pauline Young | +14 more

Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynamics, is an alternative method to anticipate drug responses. It is unclear whether integrating genomic and functional features of solid tumours can provide unique insight into therapeutic vulnerabilities. We perform combined molecular and functional characterization, via BH3 profiling of the intrinsic apoptotic machinery, in glioma patient samples and derivative models. We identify that standard-of-care therapy rapidly rewires apoptotic signaling in a genotype-specific manner, revealing targetable apoptotic vulnerabilities in gliomas containing specific molecular features (e.g., TP53 WT). However, integration of BH3 profiling reveals high mitochondrial priming is also required to induce glioma apoptosis. Accordingly, a machine-learning approach identifies a composite molecular and functional signature that best predicts responses of diverse intracranial glioma models to standard-of-care therapies combined with ABBV-155, a clinical drug targeting intrinsic apoptosis. This work demonstrates how complementary functional and molecular data can robustly predict therapy-induced cell death. Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

Oct 7, 2024 | pubs.acs.org | Bing Liu |Feng Lin |Kai Song |Yu Huang

Oct 7, 2024 | dx.doi.org | Bing Liu |Feng Lin |Kai Song |Yu Huang