Joan Röhl

Nov 6, 2024 | nature.com | Joan Röhl |Johanna Schleutker |Kenneth Muir |Henrik Grönberg |Nora Pashayan |Demetrius Albanes | +20 more

AbstractGenetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer pathogenesis.