Demetrius Albanes

Nov 6, 2024 | nature.com | Joan Röhl |Johanna Schleutker |Kenneth Muir |Henrik Grönberg |Nora Pashayan |Demetrius Albanes | +20 more

AbstractGenetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer pathogenesis.

Oct 16, 2023 | ehp.niehs.nih.gov | Ting Zhang |Kai Yu |Demetrius Albanes |Steven Moore

Per- and polyfluoroalkyl substances (PFAS), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), are persistent organic pollutants that can be ingested from contaminated drinking water and food.

May 26, 2023 | nature.com | Jianxin Shi |Kouya Shiraishi |Jiyeon Choi |Tzu-Yu Chen |Juncheng Dai |Rayjean J. Hung | +61 more

AbstractLung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci.