Demetrius Albanes

1 month ago | onlinelibrary.wiley.com | Ting Zhang |Steven Moore |Xiaoyu Wang |Demetrius Albanes

ATBC the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study AUC area under the curve BCAA branched-chain amino acid BMI body mass index CI confidence interval EN elastic net regression LASSO least absolute shrinkage and selection operator OR odds ratio PDAC pancreatic ductal adenocarcinoma PLCO the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial SD standard deviation TCA tricarboxylic acid 7-HOCA 7-α-hydroxy-3-oxo-4-cholestenoate 1 INTRODUCTION Pancreatic cancer is a major...

Nov 6, 2024 | nature.com | Joan Röhl |Johanna Schleutker |Kenneth Muir |Henrik Grönberg |Nora Pashayan |Demetrius Albanes | +20 more

AbstractGenetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer pathogenesis.

Oct 16, 2023 | ehp.niehs.nih.gov | Ting Zhang |Kai Yu |Demetrius Albanes |Steven Moore

Per- and polyfluoroalkyl substances (PFAS), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), are persistent organic pollutants that can be ingested from contaminated drinking water and food.