Joanna M. Wardlaw

Jan 6, 2025 | nature.com | Joanna M. Wardlaw

AbstractPredicting the evolution of white matter hyperintensities (WMH), a common feature in brain magnetic resonance imaging (MRI) scans of older adults (i.e., whether WMH will grow, remain stable, or shrink with time) is important for personalised therapeutic interventions.

Jan 1, 2025 | nature.com | Joanna M. Wardlaw

AbstractCerebral small vessel disease (SVD) is a vascular disorder that increases the risk of stroke and dementia and is diagnosed through brain MRI. Current primary prevention and secondary treatment of SVD are focused on lifestyle interventions and vascular risk factor control, including blood pressure reduction. However, these interventions have limited effects, a proportion of individuals with sporadic SVD do not have hypertension, and SVD shows strong familial and genetic underpinnings.

Aug 30, 2024 | jamanetwork.com | Joanna M. Wardlaw

More Reasons Not to Lower High Blood Pressure Early After Ischemic Stroke Early vs Delayed Antihypertensive Treatment in Acute Single Subcortical Infarction Yufei Wei, MD, PhD; Xuewei Xie, MD, PhD; Yuesong Pan, PhD; Mengxing Wang, PhD; Aili Wang, MD, PhD; Dacheng Liu, MD, PhD; Zilin Zhao, MD; Ximing Nie, MD, PhD; Wanying Duan, MD, PhD; Xin Liu, MD, PhD; Zhe Zhang, MD, PhD; Jingyi Liu, MD, PhD; Lina Zheng, MD, PhD; Suwen Shen, MD; Chongke Zhong, MD, PhD; Tan Xu, MD, PhD; Yong Jiang, MD, PhD;...

May 20, 2024 | nature.com | Colin Buchanan |Susana Muñoz Maniega |Joanna M. Wardlaw |Ian J Deary |Simon Cox

AbstractNeighbourhood disadvantage may be associated with brain health but the importance of exposure at different stages of the life course is poorly understood. Utilising the Lothian Birth Cohort 1936, we explored the relationship between residential neighbourhood deprivation from birth to late adulthood, and global and local neuroimaging measures at age 73.

May 24, 2023 | inkl.com | Joanna M. Wardlaw

Funded by the British Heart Foundation and in partnership with the UK Dementia Research Institute, the study involved 363 people who had experienced a lacunar stroke. Experts found the two drugs were even more effective when used in combination, and they could be available as a treatment for lacunar strokes within five years if results are confirmed in further trials.