Joanne M. Hildebrand

Nov 20, 2024 | nature.com | Shene Chiou |Vinzenz Hofferek |Joanne M. Hildebrand |Malcolm J. McConville |Kate Lawlor |Edwin Hawkins | +3 more

AbstractMixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproductive decline, however many of these attributions remain controversial.