Kate Lawlor

Nov 20, 2024 | nature.com | Shene Chiou |Vinzenz Hofferek |Joanne M. Hildebrand |Malcolm J. McConville |Kate Lawlor |Edwin Hawkins | +3 more

AbstractMixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproductive decline, however many of these attributions remain controversial.

Apr 12, 2024 | nature.com | Hirotsugu Oda |Kalpana Manthiram |Pallavi Pimpale Chavan |Shuichiro Nakabo |Mariël Swart |Nisa Celik | +22 more

AbstractThe linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death.

Jul 29, 2023 | independent.ie | Kate Lawlor

New Irish Writing’s winning story for JulyI was on the passenger side of Matt’s car on some icy road in the West, holding a stiff pillowcase to stem the red. It was one in the morning and my cheekbones quaked. “Don’t move too much,” Matt said. “It’ll go places.”It might’ve sounded like he wanted to keep the blood off his seats, but Matt was worried. I knew it in the way he smoked. Dangerously, one elbow leaning out the window into the cold.