Malcolm J. McConville

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MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions - Cell Death & Disease

Nov 20, 2024 | nature.com | Shene Chiou |Vinzenz Hofferek |Joanne M. Hildebrand |Malcolm J. McConville |Kate Lawlor |Edwin Hawkins | +3 more

AbstractMixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproductive decline, however many of these attributions remain controversial.
Accurate detection of acute sleep deprivation using a metabolomic biomarker—A machine learning approach | Science Advances

Mar 8, 2024 | science.org | Malcolm J. McConville |Clare Anderson |Andrew J. K. Phillips |Dedreia Tull |Steven W. Lockley |Shantha M. W. Rajaratnam | +4 more

A “blood-based” biomarker of sleep deprivation offers potential for future detection of sleep-related accidents.

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