Joel S. Bader

Jan 19, 2025 | nature.com | Yu Zhao |Julie Calame |Briardo Llorente |Carmen Hawthorne |Samuel Clay |Yizhi Cai | +6 more

AbstractThe Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In this paper we describe assembly and debugging of the 902,994-bp synthetic Saccharomyces cerevisiae chromosome synXVI of the Sc2.0 project.

Jan 12, 2025 | nature.com | Virginia S. Hahn |Ruin Moaddel |Joel S. Bader |Robert Gerszten |Jerome I. Rotter |Stephen S. Rich | +4 more

AbstractPeople living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure.