Joel S. Bader

Jan 12, 2025 | nature.com | Virginia S. Hahn |Ruin Moaddel |Joel S. Bader |Robert Gerszten |Jerome I. Rotter |Stephen S. Rich | +4 more

AbstractPeople living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure.