Ruin Moaddel

Jan 15, 2025 | mdpi.com | Ruin Moaddel

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Jan 12, 2025 | nature.com | Virginia S. Hahn |Ruin Moaddel |Joel S. Bader |Robert Gerszten |Jerome I. Rotter |Stephen S. Rich | +4 more

AbstractPeople living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure.

Sep 21, 2024 | biorxiv.org | Julián Candia |Giovanna Fantoni |Ruin Moaddel |Francheska Delgado-Peraza

AbstractSomaScan and Olink are the leading aptamer- and antibody-based platforms in current proteomics research, each of them capable of measuring thousands of human proteins with a broad range of endogenous concentrations. In this study, we investigated the effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification across 10,776 (11K SomaScan) and 1,472 (Olink Explore 1536) analytes, respectively.

Jul 15, 2024 | pharmrev.aspetjournals.org | Panos Zanos |Ruin Moaddel |Patrick Morris |Lace M. Riggs

AbstractKetamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. Although best characterized for its dissociative anesthetic properties, ketamine also exerts analgesic, anti-inflammatory, and antidepressant actions. We provide a comprehensive review of these therapeutic uses, emphasizing drug dose, route of administration, and the time course of these effects.

Feb 14, 2024 | medrxiv.org | Tess Peterson |Ruin Moaddel |Min Zhu |Virginia Shalkey Hahn

The authors have declared no competing interest. This study was supported in part by the National Institutes of Health (NIH: R01 HL126552 (SMASH study, KCW and WSP); U01-DA036297 (ALIVE data collection); and U01-HL146201, U01-HL146193, U01-HL146240, and U01-HL146205 (MACS, WIHS data collection).