Johan Bielecki

Jul 5, 2024 | nature.com | Leonardo Monrroy |Alfredo Bellisario |Richard Bean |Johan Bielecki |Richard A. Kirian |Romain Letrun | +6 more

AbstractDetecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce microsecond time-series of protein scattering with exceptionally low noise levels of 0.001%. We demonstrate the approach by examining Jɑ helix unfolding of a light-oxygen-voltage photosensory domain.

Feb 1, 2024 | nature.com | Gábor Bortel |Marcin Sikorski |Richard Bean |Johan Bielecki |Adam Round |Miklós Tegze | +1 more

AbstractX-ray Free Electron Lasers (XFEL) are cutting-edge pulsed x-ray sources, whose extraordinary pulse parameters promise to unlock unique applications. Several new methods have been developed at XFELs; however, no methods are known, which allow ab initio atomic level structure determination using only a single XFEL pulse. Here, we present experimental results, demonstrating the determination of the 3D atomic structure from data obtained during a single 25 fs XFEL pulse.

Jan 11, 2024 | dx.doi.org | Zhou Shen |Paul Lourdu Xavier |Richard Bean |Johan Bielecki

Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2024, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Zhou Shen Department of Physics, National University of Singapore, 117551 Singapore Max Planck Institute for the Structure and Dynamics of Matter, 22761 Hamburg, Germany Center for Free-Electron Laser Science, 22761 Hamburg, Germany , Paul Lourdu Xavier Max Planck Institute for the Structure and Dynamics of Matter, 22761 Hamburg, Germany The Hamburg Center for Ultrafast...