Johannes Kettunen

3 weeks ago | pubs.acs.org | Siyu Zhao |Corey Giles |Kevin Huynh |Johannes Kettunen

In our original article, two minor errors need corrected:(1) On page 20363, in the Materials and Methods section, under the Population Cohorts subsection, there is a wrong number given for the number of participants in the Young Finns Study (YFS). Instead of “the Young Finns Study (YFS) with 2036 participants (43 years, 55% women)”, it should be “the Young Finns Study (YFS) with 2173 participants (39 years, 55% women)”.

Nov 18, 2024 | nature.com | Coraline Borowczyk |Minna Kaikkonen |William Tressel |James B. Stein |Edward B Thorp |Emmanuel L. Gautier | +3 more

AbstractMetabolic dysregulation, including perturbed glutamine–glutamate homeostasis, is common among patients with cardiovascular diseases, but the underlying mechanisms remain largely unknown. Using the human MESA cohort, here we show that plasma glutamine–glutamate ratio is an independent risk factor for carotid plaque progression.

Jun 12, 2024 | medrxiv.org | Ville Salo |Johannes Kettunen |Eeva Sliz

The authors have declared no competing interest. E.S. was funded by Academy of Finland (grant number: 338229) and Orion Research Foundation sr. J.K. was funded by Sigrid Juselius foundation. The authors wish to acknowledge CSC - IT Center for Science, Finland, for computational resources. We also want to acknowledge the participants and investigators of FinnGen study.

Feb 23, 2023 | nature.com | Ville-Petteri Mäkinen |Johannes Kettunen |Terho Lehtimäki |Veikko Salomaa |Marjo-Riitta Järvelin

We leveraged multiple population-based cohorts and data mining algorithms to investigate how ageing manifests in metabolic measures obtained from repeated collections of blood over a decade. To make it easier to interpret multivariable statistical patterns in the data, we summarized the metabolic profiles by four representative subgroups (TG-rich, TG-poor, High LDL-C and Low lipids).