Eeva Sliz

Nov 6, 2024 | nature.com | Ville Salo |Eeva Sliz |Ene Reimann |Reedik Mägi |Priit Palta |Juhani Määttä

AbstractGiven that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding of the genetic factors influencing LDH. We perform a genome-wide association analysis (GWAS) of LDH in the FinnGen project and in Estonian and UK biobanks, followed by a genome-wide meta-analysis to combine the results.

Jun 12, 2024 | medrxiv.org | Ville Salo |Johannes Kettunen |Eeva Sliz

The authors have declared no competing interest. E.S. was funded by Academy of Finland (grant number: 338229) and Orion Research Foundation sr. J.K. was funded by Sigrid Juselius foundation. The authors wish to acknowledge CSC - IT Center for Science, Finland, for computational resources. We also want to acknowledge the participants and investigators of FinnGen study.

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.