John M. Koomen

1 week ago | nature.com | Chao Wang |Jamie K Teer |Xiaoxian Liu |Timothy Chan |Vladimir Makarov |Carmen Anadon | +6 more

AbstractCell therapy with tumor-infiltrating lymphocytes (TILs) has yielded durable responses for multiple cancer types, but the causes of therapeutic resistance remain largely unknown. Here multidimensional analysis was performed on time-serial tumor and blood in a lung cancer TIL therapy trial. Using T cell receptor sequencing on both functionally expanded T cells and neoantigen-loaded tetramer-sorted T cells, we identified tumor antigen-specific T cell receptors.

Feb 7, 2024 | nature.com | Bin Fang |Michael White |John M. Koomen |Jennifer Wargo |Jianfei Qi

AbstractMelanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mechanisms underlying these sex-associated discrepancies are poorly defined.