Jonas Cerneckis

Dec 15, 2023 | cell.com | Jonas Cerneckis |Guo-li Ming |Hongjun Song |Chuan He

HighlightsAdvanced detection of RNA modifications, especially N6-methyladenosine, paves the way for transcriptome-wide, single-cell, and stoichiometric modification profiling at single-nucleotide resolution. RNA modification databases, tumor atlases, drug-like compound libraries, and machine learning have accelerated therapeutic development focused on epitranscriptomics.

Jun 21, 2023 | cell.com | Jonas Cerneckis

How does the interplay between neurons and glial cells drive neuroinflammation in BO models of AD? What are the key events that promote microglial activation leading to neuroinflammation in AD BOs? How does a multitude of genetic and environmental risk factors for AD interact to drive disease progression in BOs? How do common and rare APOE variants affect myelin health and integrity in myelinoids?